The extract soybean of local varieties as reduce advanced glycation end products and hemoglobin a1c in type 2 diabetes mice

Christyaningsih, Juliana and Taufiqurrahman, Taufiqurrahman and Sujono, Sujono (2018) The extract soybean of local varieties as reduce advanced glycation end products and hemoglobin a1c in type 2 diabetes mice. Asian Journal of Pharmaceutical and Clinical Research, VOl.11 (11). pp. 333-336. ISSN 2455-3891

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Abstract

Objectives: Glucose and amino acids or fat in diabetic patients if were oxidized to form a compound amadori product (hemoglobin A1c [HbA1c]) and intermediate dicarbonyl that uses reactive carbonyl groups to bind with the amino acids to form advanced glycation end products (AGEs). Soybean is classified as a low index glycemic and content of polyphenol compounds are reported to have various biological activities, which are beneficial to health. Project objectives: The aim of this study was to determine the effect of extract soybean of local varieties obtained on AGEs and HbA1c.Methods: This study was a randomized pretest-posttest control group design. The amount of 28 Mus musculus Balb/C was divided into seven groups. The control group was divided four, while the test group was given extracts of three varieties of soybean, that is, Gema, Wilis, and Argomulyo at a dose equivalent to 1 g of soy/kg BW/day for 25 days. Type 2 diabetes (T2D) mice made with the administration of STZ at a dose of 55 mg/kg in mice.Results: There is a sign of differences in HbA1c levels in the group of mice, and there are different levels of AGEs, though not statistically significant in the group of mice.Conclusions: The extract soybean was a positive effect on the levels of AGEs and HbA1c in T2D mice.

Item Type:	Article
Uncontrolled Keywords:	Glycine max(L.) Merr., Advanced glycation end products, Hemoglobin A1c, Type 2 diabetes mice
Subjects:	A General Works > Food and Nutrition
Divisions:	Poltekkes Kemenkes Surabaya > Pusat Penelitan dan Pengabdian Masyarakat > Pubikasi
Depositing User:	Misnawar
Date Deposited:	19 Oct 2020 03:31
Last Modified:	28 Apr 2023 09:13
URI:	http://repo.poltekkesdepkes-sby.ac.id/id/eprint/921

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