Potensi Daun Kelor (Moringa oleifera) Terhadap Kadar Kadmium Dan Kreatinin Dalam Darah Sebagai Indikator Kerusakan Fungsi Ginjal Pada Tikus Putih Yang Terpapar Asap Rokok

Rahayuningsih, Christ Kartika and Agustin, Rya and Idayanti, Tacik (2022) Potensi Daun Kelor (Moringa oleifera) Terhadap Kadar Kadmium Dan Kreatinin Dalam Darah Sebagai Indikator Kerusakan Fungsi Ginjal Pada Tikus Putih Yang Terpapar Asap Rokok. The Journal Of Muhammadiyah Medical Laboratory Technologist, 5 (2). pp. 159-173. ISSN 2614-2805

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Abstract

High exposure of cigarettes in Indonesia causes a disturbance in the kidney’s metabolism, which is due to the cadmium metal content. Cadmium induces oxidative stress by the formation of free radicals and a decrease in antioxidants activity in the kidney (nephrotoxic). One way to overcome nephrotoxic by utilizing Moringa oleifera (MO) which is known as a "miracle plant" and have high contents of flavonoid groups, phenols, gallic acid, ascorbic acid and carotenoids as antioxidants and natural metal chelating agents. This research aimed to analyze the potential of Moringa leaves in decreasing cadmium and creatinine levels in the blood of white rats due to exposure of cigarette smoke at doses 200, 400 and 800 mg/kgwb. The type of research was an experimental study with quantitative analysis conducted in October 2021 – July 2022. The independent variable was the doses of Moringa leaves extract and the dependent variable were the blood cadmium and creatinine levels of white rats. The blood cadmium level was measured with AAS and the creatinine level was measured with Jaffe method without deproteination by photometry. Based on statistical analysis using Kruskal wallis, the p value on cadmium levels in the blood were 0.004 < 0.05 and the p value on creatinine levels was 0.003 < 0.05, showed there were significant differences in blood cadmium and creatinine levels in the treatment groups. Moringa leaf extract at a dose of 400 mg/kgwb had good potential in overcoming kidney damage in terms of creatinine levels due to cadmium exposure through cigarette smoke.

Item Type:	Article
Uncontrolled Keywords:	Moringa oleifera, Cigarettes Smoke, Cadmium, Creatinine, Rattus norvegicus
Subjects:	Q Science > QR Microbiology
Divisions:	Poltekkes Kemenkes Surabaya > Jurusan Analis Kesehatan > Program Studi DIII Teknologi Laboratorium Medis
Depositing User:	Noer Amelia
Date Deposited:	31 Jul 2024 10:21
Last Modified:	31 Jul 2024 10:21
URI:	http://repo.poltekkesdepkes-sby.ac.id/id/eprint/8447

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