Spike-Receptor Binding Domain (SRBD) Antibodies Secretion in COVID-19 Survivors and Non-Survivors Post-Pre-Endemic Vaccination

Museyaroh, Museyaroh and Woelansari, Evy Diah and Krihariyani, Dwi (2022) Spike-Receptor Binding Domain (SRBD) Antibodies Secretion in COVID-19 Survivors and Non-Survivors Post-Pre-Endemic Vaccination. Folia Medica Indonesiana, 58 (3). pp. 256-260. ISSN 2599-056X

Text 08. Hasil_SPIKE-RECEPTOR BINDING DOMAIN (SRBD) ANTIBODIES SECRETION IN COVID 19 SURVIVORS AND NON-SURVIVORS POST-PRE-ENDEMIC VACCINATION.pdf Download (1MB)

Abstract

The development of a vaccine for SARS-COV-2 began in mid-2020 with the aim of stimulating an individual's immune response against SARS-CoV-2 infection. The purpose of this study was to determine the levels of post-vaccine SRBD antibody secreted in COVID-19 survivors and non-survivors. Antibodies are considered to play a more important role in evaluating immunity because antibody tests may provide information about a person's immune status against SARS-CoV-2. The study was conducted at Husada Utama Hospital, Surabaya, Indonesia, in April – May 2021. The samples were taken prospectively with a total sample of 60 patients, consisting of 40 non-survivors and 20 survivors of COVID-19 who had received Sinovac vaccine doses 1 and 2. Examination of Sars-CoV-2 SRBD antibody was conducted by using CL series of Mindray device by means of CLIA method. The average level of antibody was assessed in each sample group and the results were subjected to the Mann Whitney test. The mean SRBD antibody level in female patients was 428.24 ± 271.25, while in male patients it was 310.40 ± 113.71 U/mL. The results of the Mann Whitney test revealed a P-Value of 0.09 > 0.05, indicating no difference in post-vaccine SRBD antibody levels between females and males, but there were differences in SRBD antibody levels in COVID-19 survivors and non-survivors with a P-Value of <, i.e. 0.00 < 0.05 There was no difference in post-vaccine SRBD antibody levels between females and males in COVID-19 survivors and non-survivors, but there were differences in post-vaccine antibody levels between COVID-19 survivors and non-survivor

Item Type:	Article
Uncontrolled Keywords:	COVID-19; SRBD; virus; good health and well-being; vaccine
Subjects:	Q Science > QR Microbiology
Divisions:	Poltekkes Kemenkes Surabaya > Jurusan Analis Kesehatan
Depositing User:	Misnawar
Date Deposited:	13 Apr 2023 02:24
Last Modified:	13 Apr 2023 02:24
URI:	http://repo.poltekkesdepkes-sby.ac.id/id/eprint/6707

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