Wardani, Novita Eka Kusuma and Respatiningrum, Respatiningrum and Laili, Anis Nur and Hidayati, Dwi Yuni Nur and Soeharto, Setyawati and Sujuti, Hidayat (2019) Cypermethrin Triggers Apoptosis, Depletes Granulosa Cells, And Induces Endometrium Thinning In Female Rats. Asian Pacific Journal of Reproduction, 8 (4). pp. 141-147. ISSN 2305-0519
Full text not available from this repository.Abstract
Objective: To analyze the effects of subchronic cypermethrin on the ovary and endometrium as well as the involvement of apoptosis in the toxicity of cypermethrin. Methods: A total of 32 female Wistar rats were randomly divided into four groups, with 8 rats in each group. The control group received no treatment, and the other three groups received oral cypermethrin at 10, 15 or 20 mg/kg body weight for 28 days (sub-chronic). The granulosa cells were calculated histopathologically. The apoptotic index was determined by in situ technique. Histopathological examination was performed on the uterus and ovary. Results: There was no significant difference in the number of primary follicular granulosa cells between the treatment groups and the control group (P>0.05). However, the number of secondary and tertiary follicle granulosa cells in the treatment groups was significantly decreased compared to that of the control group (P all<0.05). The apoptotic index of primary follicular granulosa cells increased significantly in the groups treated with cypermethrin compared with the control group (P<0.05). The secondary, tertiary, and endometrial granulosa cell apoptosis index was significantly higher in all treatment groups compared to the control group (P<0.05). The higher the dose of cypermethrin was, the higher the apoptotic index of secondary, tertiary and endometrial granulosa cells was. There was a significant decrease in endometrial thickness in the three treatment groups compared to the control group (P<0.05). Thinning of the endometrial layer was seen in the cypermethrin exposure groups. Conclusions: Exposure to cypermethrin can suppress the number of secondary and tertiary follicular granulosa cells, and trigger thinning of the endometrium through induction of apoptosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Endocrine disruptor; Pyrethroid pesticide; Uterus; Reproduction Apoptosis |
| Subjects: | R Medicine > RT Nursing |
| Divisions: | Poltekkes Kemenkes Surabaya > Pusat Penelitan dan Pengabdian Masyarakat > Penelitian |
| Depositing User: | Misnawar |
| Date Deposited: | 20 Dec 2022 01:57 |
| Last Modified: | 20 Dec 2022 01:57 |
| URI: | http://repo.poltekkesdepkes-sby.ac.id/id/eprint/6234 |
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