Maharrani, Titi and Santoso, Sanarto and Indrawan, I Wayan Agung and Irawati, Deasy and Sukesi, Sukesi (2019) The Effect of Ethanol Extract Black Cumin (Nigella sativa) on Renal ET-1 and eNOS Expression Mice Preeclampsia Model. The Effect of Ethanol Extract Black Cumin (Nigella sativa) on Renal ET-1 and eNOS Expression Mice Preeclampsia Model, 13 (4). pp. 1712-1716. ISSN 0973-9130
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2. The Effect of Ethanol Extract Black Cumin (Nigella sativa) on Renal ET-1 and eNOS Expression Mice Preeclampsia Model.pdf Download (520kB) |
Abstract
Objective: to determine the effect of Nigella sativa ethanol extract on serum sFlt-1 levels and expression of renal ET-1 mice model of preeclampsia. Method: This research was a laboratory experimental research with post test only control group design. This study used 30 BALB / C mice which were divided into 6 groups, namely negative control which was pregnant mice injected with serum of normal pregnant women, positive control was preeclampsia model mice, and treatment groups 1, 2, 3 and 4 were mouse models of preeclampsia get 500 mg, 1000 mg, 1500mg and 2000mg / kgBB / day ethanol extract of Nigella sativa for 5 days. Statistical analysis using ANOVA. Results: Mean renal ET-1 expression in mice preeclampsia model in treatment groups were 500mg, 1000mg, 1500mg and 2000mg (9.6+1.8%, 6.8+1.3%, 4.6+1.5% dan 5.4+1.5%) showed significant differences (p <0.05) and found a decrease in renal ET-1 expression with increasing dose. Same like that, mean expression of eNOS kidney showed significant differences in the treatment group dose 500mg, 1000mg, 1500mg and 2000mg (56.3±3.2%, 63.8±3.3%, 78.0±5.4%, 66.9±1.9%). Conclusion: The administration of ethanol extract of black cumin seeds (Nigella sativa) decrease renal ET-1 expression and increase renal eNOS expression mice preeclampsia model and the effect was dose dependent
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Endothelin-1, eNOS, Nigella sativa, preeclampsia |
| Divisions: | Poltekkes Kemenkes Surabaya > Pusat Penelitan dan Pengabdian Masyarakat > Pubikasi |
| Depositing User: | Retno Wulan Ningsih |
| Date Deposited: | 08 Apr 2022 08:30 |
| Last Modified: | 08 Apr 2022 08:30 |
| URI: | http://repo.poltekkesdepkes-sby.ac.id/id/eprint/4545 |
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