Potency of Ginger Extract (Zingerber Officinale Roscoe) as Antioxidant and Hepatoprotector for Liver and Pulmonary Tissue in Exposed Mice (Mus Musculus) by Organophosphate Pesticides

Rahayu, Umi and Thohari, Imam and Ngadino, Ngadino (2020) Potency of Ginger Extract (Zingerber Officinale Roscoe) as Antioxidant and Hepatoprotector for Liver and Pulmonary Tissue in Exposed Mice (Mus Musculus) by Organophosphate Pesticides. International Journal of Current Research, 12 (1). pp. 9281-9284. ISSN 0975-833X

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Abstract

Pesticides as bioactive substances contain poison for killing plant-disturbing organism. Pesticides exposure can cause damage for liver and pulmonary tissue. Each active substance that is contained in pesticides causes different symptoms of poisoning. The symptoms of poisoning (subjective complaints) which are caused as the impact of pesticides will be improved by us through providing ginger extract. Moreover, this research will be applied to mice (Mus musculus). This research aimed at analyzing the influence of providing ginger extract (Zingiber officinale Roscoe) as antioxidant against the protection of liver and pulmonary damage due to pesticides exposure in mice. Design of this research was Quasi Experimental research by using simple experimental design (Post Test Only Control Group Design). Sample in this research was healthy male Swiss Webster white mice. An examination was conducted in order to investigate tissue damage on experimental animals’ liver and pulmonary. The research result showed that there was liver cell damage in K0 group (without any treatment). Besides, there were normal cell and the lightest damage (less than 25%). In K1 group, it was occurred cell degeneration and hepatotic damage in mild, moderate, and chronic hepatocyte damage. In K3 group, it was occurred cell degeneration and hepatocyte damage in mild, moderate, and chronic level. However, improving liver cells was through providing ginger extract. Through adding ginger extract, improving damage on pulmonary organ cells was also much better. In conclusion, by providing ginger extract in mice which were exposed by pesticides had no role in repairing liver cell damage. In contrary, in pulmonary organ, it was occurred an improvement of mice’s pulmonary organ cell. Nevertheless, for further research, it needs to be conducted a research in smaller dose of ginger extract.

Item Type:	Article
Uncontrolled Keywords:	Pesticides, Ginger, Liver and Pulmonary
Subjects:	G Geography. Anthropology. Recreation > GE Environmental > Environmental Engineering > Environmental Health
Divisions:	Poltekkes Kemenkes Surabaya > Pusat Penelitan dan Pengabdian Masyarakat > Pubikasi
Depositing User:	Nanik Indra Putri Sari
Date Deposited:	02 Dec 2021 08:31
Last Modified:	02 Dec 2021 08:31
URI:	http://repo.poltekkesdepkes-sby.ac.id/id/eprint/3616

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