Parasitic Tea Scurrula atropurpurea (Blume) Danser Active Compound Potencies Towards Inhibition of DNA Methylation in Cancer: An In Silico Study

Sudiwati, Ni Luh Putu Eka and Nurseta, Tatit and Ali, Mulyohadi and Aulani'am, Aulani'am and Nugroho, Heru Santoso Wahito (2018) Parasitic Tea Scurrula atropurpurea (Blume) Danser Active Compound Potencies Towards Inhibition of DNA Methylation in Cancer: An In Silico Study. Indian Journal of Public Health Research & Development, 9 (7). pp. 206-209. ISSN 0976-5506

Text IJPHRD July. 2018 (206-209).pdf Download (748kB)

Abstract

DNA methylation is metil group (CH3) adding towards DNA. This mechanism will affected cells function and arise difference gene expression. Tumor suppresor gene hipermethylation, was silencing gene expression, induced cancer progressivity, and interfere the therapy. Recent studies have been reported that some compound from plants could act as an inhibitor on DNA methylation. Since methylation is inhibiting, the silenced tumor suppressor gene caused by hipermethylation, will be re-active. Previous study was succesfully identify flavonoid from Scurrula atropurpurea (Blume) Danser (SAD) that collected from Lawang city, Jawa Timur. Fractionation of a compound have been carried out with a solvent n-heksan, chloroform, and ethanol. Identification of a compound through investigating liquid chromatography mass specthrometry mass (LCMS). The outcome showed that flavonoid compound in SAD were included flavanon, dihidroflavonol, flavon, flavonol, katekin, and Epigallocathecin-3-O-gallate (EGCG). The study was an advanced study, has an objectives to identify the SAD potency towards methylation inhibition, and it was insilico using Autodock Vina on software PyRx 0.8. The result shown that an active compound isolated from SAD have potency to inhibit DNA methylation, in which EGCG as the strongest candidate with binding affinity was -10.4 Kcal./mol. Result of this study can be used to tested a potential active compound of SAD as anticancer both in vitro and in vivo.

Item Type:	Article
Uncontrolled Keywords:	DNA methylation, Scurrula atropurpurea (Blume) Danser
Subjects:	Q Science > Q Science (General)
Divisions:	Poltekkes Kemenkes Surabaya > Pusat Penelitan dan Pengabdian Masyarakat > Pubikasi
Depositing User:	Nanik Indra Putri Sari
Date Deposited:	14 Aug 2021 01:06
Last Modified:	14 Aug 2021 06:34
URI:	http://repo.poltekkesdepkes-sby.ac.id/id/eprint/2362

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